RESEARCH NOTE: PHOTOREACTION OF 4', 5'-DIHYDROPSORALEN WITH THYMINE |
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| Authors: | Sang Chul Shim Jong Sung Koh Hyun Kwan Shim |
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| Affiliation: | Department of Chemistry, Korea Advanced Institute of Science and Technology, P.O. Box 150 Cheongyangni, Seoul 131, Korea |
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| Abstract: | Abstract— The photocycloaddition reaction of 4',5'-dihydropsoralen with thymine was carried out in solution and in the frozen state. A major photoadduct was isolated and characterized by elemental analysis and physical methods. The photoadduct was proven to be the 1:1 C4-cycloaddition product, an analogue of furocoumarin-DNA biadduct, with the stereochemistry of anti -head-to-head formed through 2+2 addition reaction between the pyrone double bond of 4', 5'-dihydropsoralenand 5,6-double bond of thymine. |
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