咪唑盐类聚离子液体抗菌剂的制备及其在水凝胶敷料中的应用

皮肤伤口的感染严重威胁患者的生命安全,虽然传统的含有银离子或小分子抗生素的抗菌水凝胶伤口敷料具有广谱的杀菌功效,但这些抗菌水凝胶敷料中的抗菌剂存在一定的生物毒性和耐药性风险,无法满足临床长期使用的要求.咪唑盐类聚离子液体由于其含有较强的正电荷效应以及疏水链段,因此其作为新型的聚合物抗菌剂具有较强的抗菌效果.本研究首先通...

Preparation of Imidazolium Salt-based Poly(ionic liquids)Antibacterial Agent and Its Application in Hydrogel Dressing

Skin wound infections seriously threaten the lives of patients.Although traditional antibacterial hydrogels containing biocides such as silver ions or small molecule antibiotics have a broad-spectrum bactericidal effect and are used as wound dressings,the biological toxicity of silver ions and drug resistance of small molecule antibiotics cannot meet the requirements of long-term clinical application.The imidazolium salt-based poly(ionic liquids)are novel polymer antibacterial agents that exhibit strong antibacterial property,owing to their strong positive charge effect and hydrophobic polymer segments.In this study,imidazolium salt-based poly(ionic liquids)contained furan functional groups as strong antibacterial agents were synthesized by Radziszewski reaction.Then,the imidazolium salt-based poly(ionic liquids)were compounded with hyaluronic acid/polyethylene glycol by Diels-Alder“click”reaction to prepare antibacterial hydrogels.The in vitro assays show that the antibacterial hydrogels containing imidazolium salt-based poly(ionic liquids)can quickly kill bacteria and also have low toxicity towards human skin fibroblasts.This kind of hydrogels can be applied in various biomedical fields.