Conformational changes in the human serum albumin-indomethacin binding |
| |
Authors: | J Cots R Pouplana J Estelrich |
| |
Institution: | (1) Present address: Fisico-Química Biológica, Facultat de Farmàcia, Universitat de Barcelona, Spain |
| |
Abstract: | The effect of a nonsteroidal anti-inflammatory drug, the indomethacin, on the conformation of human serum albumin is investigated by evaluating -helix, -structure and random coil structure contents from optical rotatory dispersion spectra. The observed structural changes may be attributed to the -helix-to- -structure conversion, because the content of random coil is not largely changed. The increase in -structure is due to a loss in the degrees of freedom in albumin. |
| |
Keywords: | Humanserum albumin indomethacin optical rotatorydispersion protein-drug binding conformational changes |
本文献已被 SpringerLink 等数据库收录! |