| 胺类化合物与4，4’-二氟苯偶酰的亲核取代反应研究 |
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| 引用本文： | 阮继武,黄忠京,符立梧,马林,古练权.胺类化合物与4，4’-二氟苯偶酰的亲核取代反应研究[J].有机化学,2003,23(8):861-864. |
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| 作者姓名： | 阮继武 黄忠京 符立梧 马林 古练权 |
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| 作者单位： | [1]中山大学化学与化学工程学院,广州510275 [2]广西民族学院化学化工系,南宁530006 [3]中山大学肿瘤防治中心,广州510060 |
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| 基金项目： | 广东省自然科学基金 (No.0 2 1 81 3)，教育部博士点基金 (No.2 0 0 1 0 5580 0 5)资助项目 |
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| 摘 要： | 应用胺类化合物与4，4'-二氟苯偶酰的亲核取代反应合成了多种对称或不对称 的4，4'-双（二烷氨基）苯偶酰。结构经元素分析，IR，~1H NMR和MS确定，其中 伯胺与4,4'-二氟苯偶酰的反应得到了一边取代、另外一边形成亚胺结构的产物， 并对此反应机理进行了探讨。
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| 关 键 词： | 胺 二氟苯偶酰 亲核反应 取代反应 反应机理 元素分析 红外分光光度法 质子磁共振谱法 质谱法 |
Study on the Nucleophilic Substitutions of 4,4'-Difluorobenzil with Amines |
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| RUAN,Ji-Wua HUANG,Zhong-Jingb FU,Li-Wuc MA,Lina GU,Lian-Quan,a.Study on the Nucleophilic Substitutions of 4,4'-Difluorobenzil with Amines[J].Chinese Journal of Organic Chemistry,2003,23(8):861-864. |
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| Authors: | RUAN Ji-Wua HUANG Zhong-Jingb FU Li-Wuc MA Lina GU Lian-Quan a |
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| Institution: | School of Chemistry and Chemical Engineering, Zhongshan University;Department of Chemistry and Chemical Engineering, Guangxi Institute for Nationalities;Cancer Center, Zhongshan University |
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| Abstract: | Some symmetric and asymmetric 4,4'-bis(dialkylamino)benzils have been synthesized through the nudeophilic substitutions of 4, 4'-difLuorobenzil with amines. Their structures have been characterized by EA, IR, :H NMR and MS spectra. When primary amines were employed for the reaction, both the substitution and condensation occured in the substrate molecule. The mechanism of this reaction was discussed as well. |
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| Keywords: | amine difluorobenzil NUCLEOPHILIC REACTION SUBSTITUTION REACTION REACTION MECHANISM ELEMENTAL ANALYSIS IR 1HNMR MS |
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