二{氧合—二[2—呋喃甲酸二苄基锡（IV）]}的合成、性质及晶体结构

以二苄基氧化锡和2-呋喃基羧酸反应，合成了新的化合物二[氧合-二[2—呋喃甲酸二苄基锡(IV)]}．生物活性测试结果表明，该配合物具有较强的体外抗癌活性．X射线单晶衍射测定表明，配合物是以Sn2O2四元环为中心的、中心对称的二聚体结构，内环锡为六配位的畸变八面体结构，外环锡为五配位的加帽畸变三角双锥结构．

Synthesis, Anti-tumour Properties and Crystal Structure of Bis{oxo-bis[(2-furylcarboxylato)dibenzyltin(IV)]}

Bis{oxo-bis[(2-furylcarboxylato)dibenzyltin(IV)]} was synthesized by the reaction of 2-furylcarboxylic acid with the (PhCH 2) 2SnO. The compound was tested against two human tumour cell lines: MCF-7 and WiDr. The results showed that this compound had higher activities in vitro. The crystal structure was determined by X-ray diffraction study. The compound possesses centrosymmetric dimer structure mode with a four-member central endo-cyclic Sn 2O 2 unit in which the bridged oxygen atoms are tri-coordinated. Each bridged oxygen atom also connects with an exo-cyclic tin atom. The endo-cyclic tin atoms are six-coordination and have coordination geometry of distorted octahedron. The exo-cyclic tin atoms are five-coordinate and have coordination geometry of monocapped trigonal bipyramid with very similarly distorted mode.