Bacitracin and gramicidin S as inhibitors of carboxylic proteinase

Summary 1. It has been shown that polypeptide antibiotics — bacitracin and gramicidin S — inhibit carboxylic proteinases — porcine and equine pepsins. Bacitracin inhibits pepsin with K_I=2.3 mM, and gramicidin S with K_I2 mM.2. The results obtained permit a theoretical foundation for the use of bacitracin and gramicidin S and also of other polypeptide antibiotics as ligands for the biospecific chromatography of proteinases.M. V. Lomonsov State University. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 385–389, May–June, 1978.