Total synthesis of makaluvamine A/D, damirone B, batzelline C, makaluvone, and isobatzelline C featuring one-pot benzyne-mediated cyclization-functionalization |
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| Authors: | Takashi OshiyamaTakahito Satoh Kentaro OkanoHidetoshi Tokuyama |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan |
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| Abstract: | Total synthesis of pyrroloquinoline alkaloids, such as makaluvamine A/D, damirone B, batzelline C, makaluvone, and isobatzelline C, was achieved featuring a one-pot benzyne-mediated cyclization-functionalization reaction. The synthetic utility was demonstrated by the construction of the common pyrrolo[4,3,2-de]quinoline skeleton. |
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| Keywords: | Alkaloid Benzyne Cyclization One-pot reaction Pyrroloquinoline |
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