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中药药对的化学成分研究——川芎-赤芍挥发油的GC/MS分析
引用本文:李晓如,梁逸曾,杨辉,郭方遒,李晓宁,曾仲大.中药药对的化学成分研究——川芎-赤芍挥发油的GC/MS分析[J].高等学校化学学报,2006,27(3):443-448.
作者姓名:李晓如  梁逸曾  杨辉  郭方遒  李晓宁  曾仲大
作者单位:中南大学化学化工学院,中药现代化研究中心,长沙,410083
基金项目:国家自然科学基金(批准号:2017503,20235020),教育部科技创新工程重大项目培育资金(批准号:704036)资助.
摘    要:中药药对是复方的最小组成单位,具有中药配伍的基本特点. 药对化学是复方化学的核心内容. 联用色谱和化学计量学方法为中药复杂体系的分离与分辨提供了强有力的工具. 采用GC-MS法分离测定中药药对川芎-赤芍、 单味药川芎和赤芍的挥发油成分,并对其中的重叠色谱峰采用化学计量学解析方法(CRM)进行分辨,得到药对和各单味药的纯色谱曲线和质谱图,药对川芎-赤芍、 单味药川芎和赤芍分别分辨出82,78和57个色谱峰,通过质谱库对分辨的纯组分进行定性,分别得到61,52和33个定性结果,占总含量的90.18%,95.14%和95.82%.

关 键 词:药对川芎-赤芍  挥发油  气相色谱-质谱(GC-MS)  化学计量学解析法(CRM)
文章编号:0251-0790(2006)03-0443-06
收稿时间:04 28 2005 12:00AM
修稿时间:2005-04-28

Chemical Component Study of Herb Pairs in Traditional Chinese Medicine--Analysis of Volatile Oil in Rhizoma Ligustici Chuanxiong-Radix Paeoniae Rubra by GC-MS and Chemometric Resolution Method
LI Xiao-Ru,LIANG Yi-Zeng,YANG Hui,GUO Fang-Qiu,LI Xiao-Ning,ZENG Zhong-Da.Chemical Component Study of Herb Pairs in Traditional Chinese Medicine--Analysis of Volatile Oil in Rhizoma Ligustici Chuanxiong-Radix Paeoniae Rubra by GC-MS and Chemometric Resolution Method[J].Chemical Research In Chinese Universities,2006,27(3):443-448.
Authors:LI Xiao-Ru  LIANG Yi-Zeng  YANG Hui  GUO Fang-Qiu  LI Xiao-Ning  ZENG Zhong-Da
Institution:College of Chemistry and Chemical Engineering, Research Center of Modernization of Traditional Chinese Medicines, Central South University, Changsha 410083, China
Abstract:The volatile chemical components of herb pair Rhizoma Ligustici Chuanxiong-Radix Paeoniae Rubra(RLC-RPR) were analyzed by gas chromatography-mass spectrometry(GC-MS), chemometric resolution method(CRM), and overall volume integration methods. By using these methods upon two-dimensional data, 52, 33, and 61 volatile chemical components in the essential oil of RLC, RPR, and herb pair RLC-RPR were, respectively, determined qualitatively and quantitatively, accounting for 95.14%, 95.82% and 90.18% of the total contents of the essential oil of RLC, RPR and herb pair RLC-RPR, respectively. The experimental results show that the volatile chemical components of herb pair RLC-RPR in number are almost the addition of that of two single drugs RLC and RPR, but are changed in contents.
Keywords:Herb pair Rhizoma Ligustici Chuanxiong-Radix Paeoniae Rubra  Volatile oil  GC-MS  Chemometric resolution method(CRM)
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