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Synthesis and structure-activity relationship of rhodomyrtone derivatives as antibacterial agent
Authors:Sukanlaya Leejae  Boon-ek Yingyongnarongkul  Apichart Suksamrarn  Supayang Piyawan Voravuthikunchai
Affiliation:Department of Microbiology and Natural Products Research Center, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand ; Department of Chemistry and Center of Excellent of Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
Abstract:To study structure-activity relationship of rhodomyrtone against Gram-positive bacteria,structural modification of rhodo-myrtone was carried out to afford its 10 analogues.All compounds were assayed for their antibacterial potency using broth microdilution method.The results indicated that rhodomyrtone exhibited higher antibacterial activity against all Gram-positive bacteria than its analogues,with the exception of rhodomyrtone 6,8-diacetate(3) and oxime analogues 6 and 7 which demonstrated similar activity as the parent compound against Bacillus subtilis and Staphylococcus epidermidis with minimum inhibitory concentration and minimum bactericidal concentration ranged from 1 to 4μg/mL and 2 to 4μg/mL,respectively.In contrast,all analogues displayed no activity against Acinetobacter baumannii.Hydroxyl and ketone groups of rhodomyrtone were elucidated to be essential for the antibacterial property.
Keywords:Rhodomyrtone  Structure-activity relationship  Oxime analogues  Antibacterial activity
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