| (E)-脱氢二聚白藜芦醇四甲醚的全合成 |
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| 引用本文： | 张成路,邹立伟,许永廷,广东,李元东,王洋,王利东.(E)-脱氢二聚白藜芦醇四甲醚的全合成[J].应用化学,2009,26(10):1180-1183. |
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| 作者姓名： | 张成路 邹立伟 许永廷 广东 李元东 王洋 王利东 |
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| 作者单位： | (辽宁师范大学1.生物技术与分子药物研发辽宁省重点实验室，化学化工学院；2.分析中心 大连 116029) |
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| 基金项目： | 辽宁省科学技术研究（05L202）、辽宁省教育厅科学技术研究（2009A426）、辽宁省高校创新团队（2008T107）资助项目 |
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| 摘 要： | 以3, 5-二甲氧基苯甲酸(1)和对羟基苯甲醛(6)为起始原料， 经过以仿生氧化偶联为关键步骤的八步反应，对化合物10进行了全合成。通过1H NMR, 13C NMR, IR, HRMS等方法确定化合物10的结构为7, 8 - trans-7', 8'-trans-二聚芪类化合物，即(E)-脱氢二聚白藜芦醇四甲醚，结果表明利用本文方法成功合成了目标化合物。
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| 关 键 词： | 白藜芦醇 氧化偶联 二聚芪类化合物 |
| 收稿时间： | 2008-09-18 |
| 修稿时间： | 2008-12-11 |
Total Synthesis of Resveratrol (E)-dehydrodimer tetramethyl ether |
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| ZHANG Cheng-Lu,SHEN Hong-Jiang,ZOU Li-Wei,XU Yong-Ting,GUANG Dong,LI Yuan-Dong,WANG Yang,WANG Li-Dong.Total Synthesis of Resveratrol (E)-dehydrodimer tetramethyl ether[J].Chinese Journal of Applied Chemistry,2009,26(10):1180-1183. |
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| Authors: | ZHANG Cheng-Lu SHEN Hong-Jiang ZOU Li-Wei XU Yong-Ting GUANG Dong LI Yuan-Dong WANG Yang WANG Li-Dong |
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| Institution: | (1.Liaoning Key Laboratory of Biotechology and Drug Discovery,College of Chemistry and Chemical Engineering, 2.Analytical Center,Liaoning Normal University,Dalian 116029) |
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| Abstract: | The total synthesis of the title compound 10 was accomplished starting from 3, 5-dimethoxybenzoic acid (1) and p-hydroxybenzaldehyde (6) in eight steps via a strategy of biomimetic oxidative coupling. The structure of 10 which was confirmed by 1H NMR, 13C NMR, IR, HRMS analysis was 7, 8 - trans-7', 8'-trans-dimericstilbenoids (resveratrol (E)-dehydrodimer tetramethyl ether). In conclusion, the target compounds were successfully synthesized through the method in this paper. |
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| Keywords: | Oxidative coupling Resveratrol Dimeric stilbenoids |
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