Ring-opened analogues of Ambrox®: Synthesis and Structure-Odour relationships

Eight bicyclic ether derivatives 11 – 18 , related to the tricyclic odorant Ambrox^® ( 1 ) and its analogues 2 – 6 by formal heteroring-opening, have been prepared; their odoriferous activity/in activity is correlated with the steric accessibility of the ether O-atom, calculated by computer-aided molecular modeling.