Electron impact mass spectral study of thiodiglycollic acid and its ester and amide derivatives: Mechanism of loss of H2O from thiodiglycollic acid

The mechanism of H₂O loss from the molecular ion of thiodiglycollic acid is elucidated with the aid of collision-induced dissociation and deuteration experiments. These studies show that the predominant pathway for the H₂O loss involves the carboxy- and γ-methylene interaction. The fragmentation behaviour of ester and amide derivatives of thiodiglycollic acid deduced by linked-scan and high-resolution techniques is described.