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Organic phosphorus compounds. Part 3. Synthesis of 5-fluorosubstituted benzothiazolylbenzylphosphonates |
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| Authors: | Kohichiro Yoshino Noriyuki Hori Manabu Hori Tominori Morita Goro Tsukamoto |
| Abstract: | The regio specific synthesis of 5-fluorobenzothiazoles 14 has been accomplished by using difluorothiobenzanilides 13 as a key intermediate. Through this method, 5-fluorosubstituted fostedil 3 and its derivatives were synthesized and evaluated coronary vasodilator activity. |
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