Synthesis of Alkyllysophospholipid Analogues with Readily Functionalized 1-O-Alkyl Side Chain

Synthesis of alkyllysophospholipid analogues 5a and 5b are described. These lipids have imide functional group attached on the terminal of 1-O-alkyl side chain suitable for further manipulations. Our approach features the use of mesylate 8 in which the mesyl group serves both as protecting group and electrophile.