Reactions of 2-aminothiobenzamide with isocyanates: A new synthesis of 2, 3-dihydroimidazo[1, 2-c]quinazolin-5(6H)-one and 3, 4-Dihydro-2H-pyrimido[1, 2-c]quinazolin-6(7H)-one |
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Authors: | Chia-Yang Shiau Ji-Wang Chern Jung-Hsiung Tien Kang-Chien Liu |
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Abstract: | 2-(2-Chloroethylureido)- and 2-(3-chloropropylureido)thiobenzamides 5a, b were prepared in good yields by treating 2-aminothiobenzamide with 2-chloroethyl and 3-chloropropyl isocyanates respectively. Subsequent treatment of compound 5a and 5b either with alkali or mineral acid led to the formation of 2, 3-dihydro-imidazo1, 2-c]quinazolin-5(6H)-one 7a and 3, 4-Dihydro-2H-pyrimido1, 2-c]quinazolin-6(7H)-one 7b . |
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