Synthesis and 1H-, 13C-NMR analysis of some substituted 1,2,3,4-tetrahydroisoquinolines

Synthesis and ¹H-, ¹³C-nmr analysis of some substituted 3-phenyl-1,2,3,4-tetrahydroisoquinolines are reported. Spectroscopy assignments of hydrogen and carbon resonances were made on the basis of standard chemical shift theory, comparison with reference compounds, attached proton test and fully coupled ¹³C-nmr spectra. Data showed that at room temperature two conformers predominated for the 1,3-disubstituted and 1,2,3-trisubstituted isoquinolines.