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A New Investigation of Mannich Reaction
Authors:Li Yuan MOU  Zi Yun LIN  Li Ya ZHU  Xiao Tian LIANG Institute of Materia Medica  Chinese Academy of Medical Sciencesand Peking Union Medical College  Beijing Center for Biophysical Science  Engineering University of Alabama at Birmingham
Affiliation:Li Yuan MOU2,Zi Yun LIN1,Li Ya ZHU1*,Xiao Tian LIANG1 1Institute of Materia Medica,Chinese Academy of Medical Sciencesand Peking Union Medical College,Beijing 100050 2Center for Biophysical Science and Engineering University of Alabama at Birmingham
Abstract:During the synthesis of the derivatives of styryl ketonic Mannich bases, a side -product IM,other than the normal Mannich base MA, is obtained. Mannich reaction is further studied and the formation mechanism of product IM is postulated and discussed on the basis of deuterium labelling.
Keywords:Mannich reaction   side-product   styryl ketonic Mannich bases   mechanism.
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