ZnCl2-mediated stereoselective addition of terminal alkynes to D-(+)-mannofuranosyl nitrones |
| |
| Authors: | Topi? Dana Aschwanden Patrick Fässler Roger Carreira Erick M |
| |
| Institution: | Laboratorium für Organische Chemie, ETH H?nggerberg, CH-8093 Zürich, Switzerland. |
| |
| Abstract: | reaction: see text] An optimized process for the addition of terminal alkynes to chiral nitrones using ZnCl2 and NEt3 in toluene is reported. The new reaction protocol is facile to perform and cost-effective. The resulting optically active propargyl N-hydroxylamines are isolated in good to excellent yield and high diastereoselectivity. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
