The Synthesis of an Optically Active Intermediate of A-Ring for 1α,25-Dihydroxy Vitamin D_3 Analogs 期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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The Synthesis of an Optically Active Intermediate of A-Ring for 1α,25-Dihydroxy Vitamin D_3 Analogs

作者姓名：	Yong WU and

作者单位：	Yong WU; and (School of Pharmacy，West China University of Medical Sciences，Chengdu 610041)Mei GUAN (The First Hospital，West China University of Medical Sciences，Chengdu 610041)

摘要：	Asla,25-dihydr0xyvitaminD31,thehorm0nallyactiveformofvitandnD3incalciumhomoeostasis,caninducecelIdifferentiationandinhibitcellproliferation',thesynthesis0f1anditsanalogshaveattfactedmuchinterestz-.Recently,TrostandHanson5havereportedabrilliantstrategyf0rthesynthesis0f1,whichemploysacyclizationofthel,7-enyne3aandthevinylbr0mide2as0utlinedinScheme1.However,theysynthesizedthekeyintermediate4a,startingfromethyl4-chloroacetoacetatewhichhasalowstereoselectivityandisanexpensivereagent.Inthispaper,w…
关键词：	1α 25-dihydroxyvitamin D_3 D( )-xylose synthesis
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