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Pd-catalyzed copper-free carbonylative Sonogashira reaction of aryl iodides with alkynes for the synthesis of alkynyl ketones and flavones by using water as a solvent |
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| Authors: | Liang Bo Huang Mengwei You Zejin Xiong Zhengchang Lu Kui Fathi Reza Chen Jiahua Yang Zhen |
| Institution: | Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, College of Chemistry, School of Pharmaceutical Science, ShenZhen Graduate School, Peking University, Beijing 100871, China. |
| Abstract: | The Pd-catalyzed copper-free carbonylative Sonogashira coupling reaction to synthesize alkynyl ketones from terminal alkynes and aryl iodides was achieved by using water as a solvent. The reaction was carried out at room temperature under balloon pressure of CO with Et(3)N as a base. The developed method was successfully applied to the synthesis of flavones. |
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