Total synthesis of (-)-callipeltoside A |
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Authors: | Hoye Thomas R Danielson Michael E May Aaron E Zhao Hongyu |
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Institution: | Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States. hoye@umn.edu |
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Abstract: | A total synthesis of (-)-callipeltoside A (1) has been achieved. The core macrocycle was made via a dual macrolactonization/pyran hemiketal formation reaction, developed to circumvent issues related to the reversible nature of acylketene formation from β-keto lactone substrates. Initial approaches to the core of the natural product that revolved around ring-closing metathesis (RCM) and relay ring-closing metathesis (RRCM) reactions are also described. |
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