Asymmetric reduction of ketones with sodium aluminum hydride modified with chiral amino alcohols |
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| Authors: | M G Vinogradov O V Mikhalev V A Pavlov V A Ferapontov O R Malyshev G L Heise |
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| Institution: | (1) N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation;(2) One Meadowlands Plaza, Cambrex Corporation, East Rutherford, NJ 07073, USA |
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| Abstract: | Asymmetric reduction of ketones with hydride complexes, which were prepared by in situ modification of NaAlH4, with various chiral amino alcohols or diamines, was studied. The highest enantioselectivity (up to 93% ee) was achieved using 2-(hydroxydiphenylmethyl)pyrrolidine as a chiral inducing agent. |
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| Keywords: | ketones sodium aluminum hydride chiral alcohols amino alcohols diamines asymmetric reduction |
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