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Preparation, characterization and properties of novel covalently surface-functionalized zinc oxide nanoparticles |
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| Authors: | Moriyuki Sato Hajime Harada Yasuhisa Fujita Takeshi Urano |
| Affiliation: | a Faculty of Science and Engineering, Shimane University, 1060 Nishikawatsu, Matsue, Shimane 690-8504, Japan b Research Project Promotion Institute, Shimane University, 89-1 Enya, Izumo, Shimane 693-8501, Japan c Department of Biochemistry, Shimane University School of Medicine, 89-1 Enya, Izumo, Shimane 693-8501, Japan d Department of Cooperative Medical Research, Collaboration Center, Shimane University, 89-1 Enya, Izumo, Shimane 693-8501, Japan |
| Abstract: | Novel covalently surface-modified zinc oxide (ZnO) nanoparticles (NP) (ZHIE) were successfully prepared, which have organic chains composed of hydrophilic amide and urethane linkages, and terminal amino groups on the surfaces, using zinc acetate monohydrate. FTIR spectroscopy, X-ray analysis and TEM observation suggested that the resultant ZHIE NPs have the mean sizes of about 10 nm in diameters, the organic chains linking the amino groups in the terminals and wurtzite crystal structure. UV-vis absorption spectrum of the ZHIE NPs in methanol showed maximum absorption band at 348 nm, supporting the TEM observations. Photoluminescent spectrum measurements depicted that the ZHIE NPs show broad visible emission band on the basis of trapped-electron emission. Cytotoxicity and phagocytosis assays suggested that the ZHIE NPs are noncytotoxic, and the ZHIE-labeled zymosan particles derived by conjugation of the ZHIE NPs with zymosan are internalized into the cells and generate fluorescence based on the ZHIE NPs. |
| Keywords: | Surface functionalization Zinc oxide nanoparticle UV-vis absorption Visible emission Noncytotoxicity |
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