Biomimetic Nanocomposites Camouflaged with Hybrid Cell Membranes for Accurate Therapy of Early-Stage Glioma |
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| Authors: | Siyu Chi Li Zhang Hemei Cheng Yaran Chang Dr Yaoyao Zhao Prof Xiayan Wang Prof Zhihong Liu |
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| Institution: | 1. College of Chemistry and Molecular Sciences, Wuhan University, 430072 Wuhan, P.?R. China;2. College of Health Science and Engineering, Hubei University, 430062 Wuhan, P.?R. China;3. Center of Excellence for Environmental Safety and Biological Effect, Department of Chemistry, Beijing University of Technology, 100124 Beijing, P.?R. China |
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| Abstract: | Glioma features high fatality rate and short survival time of patients due to its fast growth speed and high invasiveness, hence timely treatment of early-stage glioma is extremely important. However, the blood brain barrier (BBB) severely prevents therapeutic agents from entering the brain; meanwhile, the non-targeted distribution of agents always causes side effects to vulnerable cerebral tissues. Therefore, delivery systems that possess both BBB penetrability and precise glioma targeting ability are keenly desired. We herein proposed a hybrid cell membrane (HM) camouflage strategy to construct therapeutic nanocomposites, in which HM consisting of brain metastatic breast cancer cell membrane and glioma cell membrane was prepared with a simple membrane fusion pathway. By coating HM onto drug-loaded nanoparticles, the as-obtained biomimetic therapeutic agent (termed HMGINPs) inherited satisfying BBB penetrability and homologous glioma targeting ability simultaneously from the two source cells. HMGINPs exhibited good biocompatibility and superior therapeutic efficacy towards early-stage glioma. |
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| Keywords: | Biomimetic Nanocomposites Blood-Brain Barrier Glioma Inhibition Homologous Targeting Hybrid Cell Membranes |
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