Spiroligomer-Based Macrocycles for Atomically Precise Membranes |
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Authors: | Dr Yihui Xie Danni Luo Jesse A Wiener Dr Alexander B Koval Dr Conrad T Pfeiffer Prof Christian E Schafmeister |
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Institution: | Department of Chemistry, Temple University, 1901N. 13th St., Philadelphia, PA-19122 USA |
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Abstract: | Here, we report a new class of peptidomimetic macrocycles with well-defined three-dimensional structures and low conformational flexibility. They are assembled from fused-ring spiro-ladder oligomers (spiroligomers) by modular solid-phase synthesis. Two-dimensional nuclear magnetic resonance confirms their shape persistency. Triangular macrocycles of tunable sizes assemble into membranes with atomically precise pores, which exhibit size and shape-dependent molecular sieving towards a series of structurally similar compounds. The exceptional structural diversity and stability of spiroligomer-based macrocycles will be explored for more applications. |
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Keywords: | Atomic Precision Macrocycles Membranes Molecular Sieving Spiroligomers |
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