Dandelion flower-like micelles |
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| Authors: | Yongchao Yao Deqiu Xu Yuhong Zhu Xin Dai Yunlong Yu Jianbin Luo Shiyong Zhang |
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| Institution: | National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu 610064 China.; College of Chemistry and Environmental Protection Engineering, Southwest Minzu University, Chengdu 610041 China.; Sichuan Guojian Inspection Co., Ltd., 646000 Luzhou Sichuan China |
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| Abstract: | Dandelion flower-like micelles (DFMs) were prepared by self-assembly of polycaprolactone (PCL) functionalized surface cross-linked micelles (SCMs). Upon reductive stimuli, the SCMs can be released from the DFMs by non-Brownian motion at an average speed of 19.09 μm s−1. Similar to the property of dandelion flowers dispersing their seeds over a long distance, the DFMs demonstrated enhanced multicellular tumor spheroid (MTS) penetration, a useful property in the treatment of many diseases including cancer, infection-of-biofilm diseases and ocular problems.Dandelion flower-like micelles (DFMs) can release surface cross-linked micelles (SCMs) by non-Brownian motion at an average speed of 19.09 μm s−1 upon reductive stimuli. |
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