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Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer |
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| Authors: | Metin YILDIRIM Mehmet ERSATIR Badel ARSLAN Elife Sultan G&#x;RAY |
| Institution: | 1. Department of Pharmacy Services, Vocational School of Health Services, Tarsus University, Mersin, Turkey ; 2. Department of Chemistry, Arts and Science Faculty, Çukurova University, Adana, Turkey ; 3. Department of Stem Cell and Regenerative Medicine, Institute of Health Science, Mersin University, Mersin, Turkey |
| Abstract: | 3-acetyl coumarin derivatives (1a-d) are formed as a result of condensation of salicylaldehyde derivatives and ethyl acetoacetate and were converted into coumarin-selenophene hybrid compounds (2a-d) in the basic medium by modified Gewald reaction in the presence of malononitrile and selenium. Products are characterized by nuclear magnetic resonance (NMR). The prepared compounds are screened for their anticancer activity against DU-145 cell line. In addition, selected target compounds are evaluated for apoptosis and oxidative stress on DU-145 (prostate carcinoma) cell lines. |
| Keywords: | Coumarin selenophene antitumor agents antioxidant activity heterocycles |