Metal-free entry to phosphonylated isoindoles by a cascade of 5-exo-dig cyclization, a [1,3]-alkyl shift, and aromatization under microwave heating |
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| Authors: | Dieltiens Nicolai Stevens Christian V |
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| Institution: | Research Group SynBioC, Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, B-9000 Ghent, Belgium. |
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| Abstract: | reaction: see text] When o-ethynylbenzyl alpha-aminophosphonates are heated under microwave conditions, a rearrangement occurs which results in the formation of phosphonylated isoindoles. The rearrangement consists of a 5-exo-dig cyclization followed by a 1,3]-alkyl shift and finally aromatization. |
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