Hyphenated HPLC/ICP-MS and HPLC/ICP-OES techniques for the characterization of metal and non-metal species |
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| Authors: | Jörg Schöppenthau and Lothar Dunemann |
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| Institution: | (1) Department of Analytical Chemistry, Medizinisches Institut für Umwelthygiene, Heinrich-Heine-Universitat Düsseldorf, Auf'm Hennekamp 50, D-40225 Düsseldorf, Germany |
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| Abstract: | Ion-pair and ion-exchange chromatography were used for the separation of model substances like metal-EDTA and metal-peptide complexes. Real samples like food extracts and human serum were separated by size-exclusion chromatography. The HLPC/ICP coupling was simply realized by connecting the column outlet of the chromatographic system with the nebulizer of the element specific detection systems ICP-OES and ICP-MS, respectively. In food extracts a correlation was found between zinc and sulfur as well as between copper and phosphorus; all measured metals were exclusively present in the 10–14 kD range. Copper in the 68 kD region was found to be correlated with sulfur in serum.Dedicated to Prof. Dr. Wilhelm Fresenius on the occasion on his 80th birthday |
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