Interactions of porphyrin covalently attached to poly(methacrylic acid) with liposomal membranes |
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Authors: | Kepczyński Mariusz Karewicz Anna Górnicki Andrzej Nowakowska Maria |
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Institution: | Faculty of Chemistry, Jagiellonian University, 30-060 Kraków, Ingardena 3, Poland. |
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Abstract: | The interactions between the 5-(4-acryloyloxyphenyl)-10,15,20-tritolylporphyrin covalently attached to poly(methacrylic acid) chain (PMA-Po) and phosphatidylcholine liposomes in aqueous solution at different pH values were studied. The binding constants (K(b)) for the liposome- PMA-Po in solutions in the pH range from 6.5 to 9.2 were determined using fluorescence spectroscopy. The binding was found to be efficient. The acid-base properties of the porphyrin chromophores were also studied. Both pK values associated with imine-N protonation of the porphyrin core were found to be 6.4. The quantum yield (Phi(Delta)) of singlet oxygen production by Po in the lipid-PMA-Po system was found to be high (0.88 +/- 0.05). |
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