Three-component synthesis of 3,4-dihydroisoquinoline derivatives |
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| Authors: | Shklyaev Yu. V. Nifontov Yu. V. |
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| Affiliation: | (1) Ural Branch of the Russian Academy of Sciences, Institute of Technical Chemistry, 13 ul. Lenina, 614000 Perm, Russian Federation |
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| Abstract: | A simple and convenient method for the synthesis of 1-substituted 3,3-dimethyl-3,4-dihydroisoquinolines was developed. The method is based on the [2+2+2] cyclization of alkyl- or alkoxybenzenes with isobutyraldehyde and nitriles. |
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| Keywords: | the Ritter reaction the Baeyer reaction 3,3-dimethyl-3,4-dihydroisoquinoline isobutyraldehyde nitriles veratrole 1,4-dimethoxybenzene o- and p-xylenes toluene three-component synthesis |
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