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| HPLC测定对乙酰氨基酚氯美扎酮分散片的含量 | |
| 引用本文： | 王淑君,梁爱葵,姚家元,孟祥军. HPLC测定对乙酰氨基酚氯美扎酮分散片的含量[J]. 光谱实验室, 2010, 27(3): 863-866 |
| 作者姓名： | 王淑君 梁爱葵 姚家元 孟祥军 |
| 作者单位： | 1. 沈阳一天生物制药有限公司,沈阳市经济技术开发区开发大路7甲3号,110027 2. 沈阳市医药国有资产经营有限责任公司,沈阳市和平区市府大路106号,110002 3. 沈阳医学院,沈阳市皇姑区黄河北大街146号,110034 |
| 摘 要： | 采用KromasilC4(200×4.6mm;5μm),以甲醇-水-冰乙酸(27∶63∶0.9)为流动相,检测波长为227nm,对乙酰氨基酚和氯美扎酮浓度分别在0.035—0.212mg/mL和0.008—0.048mg/mL范围内线性关系良好(r=0.9996和r=0.9999),平均回收率分别为100.0%和100.0%。本法简便,快速、重现性好,回收率高,且可同时测定对乙酰氨基酚氯美扎酮分散片中两组分的含量,并可用于其质量控制。 |
| 关 键 词： | 对乙酰氨基酚氯美扎酮分散片 高效液相色谱法 |
Determination of Paracetamol and Chlormezanone Dispersble Tablets by HPLC |
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| WANG Shu-Jun,LIANG Ai-Kui,YAO Jia-Yuan,MENG Xiang-Jun. Determination of Paracetamol and Chlormezanone Dispersble Tablets by HPLC[J]. Chinese Journal of Spectroscopy Laboratory, 2010, 27(3): 863-866 | |
| Authors: | WANG Shu-Jun LIANG Ai-Kui YAO Jia-Yuan MENG Xiang-Jun |
| Affiliation: | WANG Shu-Jun LIANG Ai-Kui YAO Jia-Yuana MENG Xiang-Junb(Shengyang Yitian Biological Pharmaceutical Limited Company,Shenyang 110027,P.R.China)a(Shengyang Medical State Property Management Co.,Ltd.,Shengyang 110002,P.R.China)b(Shenyang Medical College,Shenyang 110034,P.R.China) |
| Abstract: | Paracetamol and chlormezanone dispersble tablets were determined by HPLC with Kromasil-C4 column （200×4.6mm;5μm）,mobile phase of methanol-water-HAc（27：63：0.9）and the detective wavelength of 227nm.Good linear relationship was achieved when the concentration of paracetamol and chlormezanone were 0.035—0.212mg/mL,0.008—0.048mg/mL,respectively.The average recovery rates were 100.0% and 100.0% respectively.The method is convenient,fast,reproducible and with high recovery rates,which can be used to determine the contents of paracetamol and chlormezanone dispersble tablets simultaneously,and control the quality. |
| Keywords: | Paracetamol and Chlormezanone Dispersble Tablets HPLC |
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