Surface modification of magnetite nanoparticle with azobenzene-containing water dispersible polymer |
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Authors: | Pawinee Theamdee Rakchart Traiphol Boonjira Rutnakornpituk Uthai Wichai Metha Rutnakornpituk |
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Institution: | (1) Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Naresuan University, Phitsanulok, 65000, Thailand; |
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Abstract: | We here report the synthesis of magnetite nanoparticle (MNP) grafted with poly (ethylene glycol) methyl ether methacrylate
(PEGMA)-azobenzene acrylate (ABA) statistical copolymer via atom transfer radical polymerization (ATRP) for drug entrapment
and photocontrolled release. MNP was synthesized via thermal decomposition of iron (III) acetylacetonate in benzyl alcohol
and surface functionalized to obtain ATRP initiating sites. Molar compositions of the copolymer on MNP surface were systematically
varied (100:0, 90:10, 70:30, and 50:50 of PEGMA:ABA, respectively) to obtain water dispersible particles with various amounts
of azobenzene. The presence of polymeric shell on MNP core was evidenced by transmission electron microscopy (TEM). Drug loading
and entrapment efficiencies as well as drug release behavior of the copolymer–MNP complexes were investigated. It was found
that when percent of ABA in the copolymers was increased, entrapment and loading efficiencies of prednisolone model drug were
enhanced. Releasing rate and percent of the released prednisolone of the complex exposed in UV light were slightly enhanced
as compared to the system without UV irradiation. This copolymer–MNP complex with photocontrollable drug release and magnetic
field-directed properties is warranted for further studies for potential uses as a novel drug delivery vehicle. |
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