Facile Preparation of Core–Shell Magnetic Metal–Organic Framework Nanospheres for the Selective Enrichment of Endogenous Peptides |
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| Authors: | Dr Zhichao Xiong Dr Yongsheng Ji Chunli Fang Quanqing Zhang Prof Lingyi Zhang Prof Mingliang Ye Prof Weibing Zhang Prof Hanfa Zou |
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| Institution: | 1. Shanghai Key Laboratory of Functional Materials Chemistry, Department of Chemistry and Molecular Engineering, East China University of Science and Technology (ECUST), 130 Meilong Road, Shanghai, 200237 (P.R. China), Fax: (+86)?021‐64233161;2. Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), 457 Zhongshan Road, Dalian, 116023 (P.R. China), Fax:(+86)?0411‐84379620;3. College of Pharmacy, Henan University of Traditional Chinese Medicine, 1 Jinshui Road, Zhengzhou, 450008 (P.R. China) |
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| Abstract: | Facile preparation of core–shell magnetic metal–organic framework nanospheres by a layer‐by‐layer approach is presented. The nanospheres have high surface area (285.89 cm2 g?1), large pore volume (0.18 cm3 g?1), two kinds of mesopores (2.50 and 4.72 nm), excellent magnetic responsivity (55.65 emu g?1), structural stability, and good dispersibility. The combination of porosity, hydrophobicity, and uniform magnetism was exploited for effective enrichment of peptides with simultaneous exclusion of high molecular weight proteins. The nanospheres were successfully applied in the selective enrichment of endogenous peptides in human serum. |
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| Keywords: | core– shell structures magnetic properties metal– organic frameworks nanoparticles peptides |
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