Design and Fabrication of a Biomimetic Nanochannel for Highly Sensitive Arginine Response in Serum Samples |
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| Authors: | Dr Miaomiao Song Dr Zhongyue Sun Cuiping Han Demei Tian Prof Haibing Li Prof Lei Jiang |
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| Institution: | 1. Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079 (P.R. China);2. Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190 (P.R. China) |
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| Abstract: | Inspired from their biological counterparts, chemical modification of the interior surface of nanochannels with functional molecules may provide a highly efficient means to control ionic or molecular transport through nanochannels. Herein, we have designed and prepared a aldehyde calix4]arene (C4AH), which was attached to the interior surface of a single nanochannel by using a click reaction, and that showed a high response for arginine (Arg). Furthermore, the nanofluidic sensing system has been challenged with complex matrices containing a high concentration of interfering sequences and serum. Based on this finding, we believe that the artificial nanochannel can be used for practical Arg‐sensing devices, and be applied in a biological environment. |
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| Keywords: | arginine calixarene click chemistry nanochannel sensor |
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