Yoctowell Cavities on Magnetic Silica Nanoparticles for pH Stimuli‐Responsive Controlled Release of Drug Molecules |
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Authors: | Dr Sheshanath V Bhosale |
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Institution: | School of Applied Sciences, RMIT University, GPO Box 2476?V, Melbourne, VIC‐3001 (Australia), Fax: (+61)?3‐9925‐3747 |
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Abstract: | Drug‐delivery systems that medically transport active molecules to diseased cells, in a controlled manner, have gained much attention in recent years. Yoctowell (1 yL=8 nm3 that is, 10?24 L volume) cavities on magnetic silica nanoparticles were used for the encapsulation and release of the drug molecule, “mitoxantrone ( MTZ )”, and controlled using naturally occurring stimuli, that is, pH. First, MTZ was encapsulated from a bulk solution under physiological conditions, and then released from the yoctowells, in a controlled manner, by manipulating the pH (7.2–3.0). The sustained release of MTZ , the recovery of active yoctowells after the release process and magnetic properties of nanoparticles provide potential for development of a new generation of drug‐delivery system. |
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Keywords: | drug delivery magnetic nanoparticles pH control self‐assembly yoctowell cavities |
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