Direct α‐Siladifluoromethylation of Lithium Enolates with Ruppert‐Prakash Reagent via CF Bond Activation期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Direct α‐Siladifluoromethylation of Lithium Enolates with Ruppert‐Prakash Reagent via CF Bond Activation

Authors:	Ryota Hashimoto Toshiaki Iida Dr Kohsuke Aikawa Prof Dr Shigekazu Ito Prof Dr Koichi Mikami

Institution:	Department of Applied Chemistry, Tokyo Institute of Technology, O‐okayama, Meguro‐ku, Tokyo 152‐8552 (Japan)

Abstract:	The direct α‐siladifluoromethylation of lithium enolates with the Ruppert–Prakash reagent (CF₃TMS) is shown to construct the tertiary and quaternary carbon centers. The Ruppert–Prakash reagent, which is versatile for various trifluoromethylation as a trifluoromethyl anion (CF₃^?) equivalent, can be employed as a siladifluoromethyl cation (TMSCF₂⁺) equivalent by C?F bond activation due to the strong interaction between lithium and fluorine atoms.

Keywords:	C F activation difluoromethylation lithium enolate Ruppert– Prakash reagent umpolung