Direct Trifluoromethylthiolation of Alcohols under Mild Reaction Conditions: Conversion of ROH into RSCF3期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Direct Trifluoromethylthiolation of Alcohols under Mild Reaction Conditions: Conversion of ROH into RSCF3

Authors:	Pavlo Nikolaienko Roman Pluta Prof. Dr. Magnus Rueping

Affiliation:	Institute of Organic Chemistry, Institution RWTH Aachen University, Landoltweg 1, 52074 Aachen (Germany)

Abstract:	A direct process for the trifluoromethylthiolation of allylic and benzylic alcohols under mild conditions has been developed. A wide range of free alcohols underwent nucleophilic substitution in the presence of stable CuSCF₃ and BF₃ ? Et₂O to give the corresponding products in good to excellent yields.

Keywords:	alcohols nucleophilic substitution thioethers trifluoromethyl sulfenylation