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Revisiting the Bromination of CH Bonds with Molecular Bromine by Using a Photo‐Microflow System |
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| Authors: | Dr Yoshiyuki Manabe Yuriko Kitawaki Masahiro Nagasaki Prof Koichi Fukase Prof Hiroshi Matsubara Yoshiko Hino Prof Takahide Fukuyama Prof Ilhyong Ryu |
| Institution: | 1. Department of chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560‐0043 (Japan), Fax: (+81)?6‐6850‐5391;2. Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599‐8531 (Japan) |
| Abstract: | The photobromination of C?H bonds by using molecular bromine was reinvestigated under microfluidic conditions. The continuous‐flow method suppressed the production of dibrominated compounds and effectively produced the desired monobrominated products with high selectivity. Rapid bromination of benzylic substrates containing a photoaffinity azide group was achieved without any decomposition. |
| Keywords: | bromination bromine microreactors photoreactions |