NIS‐Assisted Aza‐Friedel–Crafts Reaction with α‐Carbamoysulfides as Precursors of N‐Carbamoylimines |
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| Authors: | Dr Nicolas George Mathieu Bekkaye Dr Aurélien Alix Prof?Dr Jieping Zhu Dr Géraldine Masson |
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| Institution: | 1. Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif‐sur‐Yvette Cedex (France), Fax: (+33)?1‐69077247;2. Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), EPFL‐SB‐ISIC‐LSPN, 1015 Lausanne (Switzerland) |
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| Abstract: | A general and practical N‐iodosuccinimide (NIS)‐promoted aza‐Friedel–Crafts reaction of various aromatic nucleophiles with N‐acylimines generated in situ from α‐amidosulfides to give a rapid access to highly functionalized amines is described. The newly developed methodology is very mild, fast, efficient, and complementary. |
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| Keywords: | Friedel– Crafts reaction imines N‐iodosuccinimide multicomponent reactions tandem reactions |
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