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CH Oxygenation and N‐Trifluoroacylation of Arylamines Under Metal‐Free Conditions: A Convenient Approach to 2‐Aminophenols and N‐Trifluoroacyl‐ortho‐aminophenols |
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| Authors: | Vunnam Venkateswarlu K A Aravinda Kumar Shilpi Balgotra G Lakshma Reddy M Srinivas Dr Ram A Vishwakarma Dr Sanghapal D Sawant |
| Institution: | Medicinal Chemistry Division, CSIR‐Indian Institute of Integrative Medicine and AcSIR, Canal Road, Jammu‐180 001 (India) |
| Abstract: | Direct ortho‐hydroxylation through C?H oxygenation and N‐trifluoroacylation of anilines was achieved in a single step under metal‐free conditions by using a combination of TFA and oxone. The method allowed the formation of functionalised amino phenolic compounds such as ortho‐hydroxy‐N‐trifluoroacetanilides in good yields with broad substrate scope. |
| Keywords: | arylamines C H oxygenation hydroxylation oxone N‐trifluoroacylation |