Nucleic Acid Based Logical Systems |
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| Authors: | Dr Da Han Dr Huaizhi Kang Dr Tao Zhang Cuichen Wu Dr Cuisong Zhou Dr Mingxu You Prof?Dr Zhuo Chen Prof?Dr Xiaobing Zhang Prof?Dr Weihong Tan |
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| Institution: | 1. Center for Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL (USA), Fax: (+1)?352‐392‐1679;2. Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian (P.R. China);3. Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio‐Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha, Hunan (P.R. China) |
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| Abstract: | Researchers increasingly visualize a significant role for artificial biochemical logical systems in biological engineering, much like digital logic circuits in electrical engineering. Those logical systems could be utilized as a type of servomechanism to control nanodevices in vitro, monitor chemical reactions in situ, or regulate gene expression in vivo. Nucleic acids (NA), as carriers of genetic information with well‐regulated and predictable structures, are promising materials for the design and engineering of biochemical circuits. A number of logical devices based on nucleic acids (NA) have been designed to handle various processes for technological or biotechnological purposes. This article focuses on the most recent and important developments in NA‐based logical devices and their evolution from in vitro, through cellular, even towards in vivo biological applications. |
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| Keywords: | DNA computation DNA nanobiotechnology logical systems nucleic acids |
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