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A Two‐Armed Lanthanoid‐Chelating Paramagnetic NMR Probe Linked to Proteins via Thioether Linkages |
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| Authors: | Dr Wei‐Min Liu Dr Simon P Skinner Dr Monika Timmer Anneloes Blok Dr Mathias A S Hass Dr Dmitri V Filippov Dr Mark Overhand Prof?Dr Marcellus Ubbink |
| Institution: | Leiden Institute of Chemistry, Leiden University, Post Office Box 9502, 2300 RA Leiden (The Netherlands) |
| Abstract: | Paramagnetic NMR probes provide valuable long‐range structural information on proteins and protein complexes. A new, stable, two‐armed lanthanoid probe is reported that can be attached to a protein site‐specifically via chemically inert thioether linkages. |
| Keywords: | lanthanides paramagnetic NMR protein modification protein structures pseudocontact shift |