Regio‐ and Enantioselective Synthesis of N‐Allylindoles by Iridium‐Catalyzed Allylic Amination/Transition‐Metal‐Catalyzed Cyclization Reactions |
| |
| Authors: | Ke‐Yin Ye Prof. Li‐Xin Dai Prof. Shu‐Li You |
| |
| Affiliation: | State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (P. R. China) |
| |
| Abstract: | Regio‐ and enantioselective synthesis of N‐allylindoles was realized through an iridium‐catalyzed asymmetric allylic amination reaction with 2‐alkynylanilines and subsequent transition‐metal‐catalyzed cyclization reactions. The highly enantioenriched allylic amines prepared from Ir‐catalysis were treated with catalytic amount of NaAuCl4 ? 2 H2O or PdCl2 providing various substituted N‐allylindoles in excellent yields and enantioselectivities. |
| |
| Keywords: | allylic substitution N‐allylindole asymmetric catalysis enantioselectivity iridium |
|
