A Novel Hybrid Metal–Organic Framework–Polymeric Monolith for Solid‐Phase Microextraction

This study describes the fabrication of a novel hybrid metal–organic framework– organic polymer (MOF–polymer) for use as a stationary phase in fritless solid‐phase microextraction (SPME) for validating analytical methods. The MOF–polymer was prepared by using ethylene dimethacrylate (EDMA), butyl methacrylate (BMA), and an imidazolium‐based ionic liquid as porogenic solvent followed by microwave‐assisted polymerization with the addition of 25 % MOF. This novel hybrid MOF–polymer was used to extract penicillin (penicillin G, penicillin V, oxacillin, cloxacillin, nafcillin, dicloxacillin) under different conditions. Quantitative analysis of the extracted penicillin samples using the MOF–organic polymer for SPME was conducted by using capillary electrochromatography (CEC) coupled with UV analysis. The penicillin recovery was 63–96.2 % with high reproducibility, sensitivity, and reusability. The extraction time with the proposed fabricated SPME was only 34 min.