Extremely Fast Gas/Liquid Reactions in Flow Microreactors: Carboxylation of Short‐Lived Organolithiums |
| |
| Authors: | Dr. Aiichiro Nagaki Yusuke Takahashi Prof. Jun‐ichi Yoshida |
| |
| Affiliation: | Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University Nishikyo‐ku, Kyoto, 615‐8510 (Japan), Fax: (+81)?75‐383‐2727 |
| |
| Abstract: | Carboxylation of short‐lived organolithiums bearing electrophilic functional groups such as nitro, cyano, and alkoxycarbonyl groups with CO2 to give carboxylic acids and active esters was accomplished in a flow microreactor system. The successful reactions indicate that gas/liquid mass transfer and the subsequent chemical reaction with CO2 are extremely fast. |
| |
| Keywords: | carboxylation flow chemistry lithiation mass transfer microreactors |
|
|
