Synthesis of Fluorinated Heteroaromatics through Formal Substitution of a Nitro Group by Fluorine under Transition‐Metal‐Free Conditions |
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| Authors: | Ran‐Ning Guo Xian‐Feng Cai Lei Shi Zhang‐Pei Chen Prof Yong‐Gui Zhou |
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| Institution: | 1. State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (P. R. China), Fax: (+86)?411‐84379220;2. Department of Chemistry, Dalian University of Technology, Dalian 116012 (P. R. China) |
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| Abstract: | An efficient and transition‐metal‐free approach was developed to access a series of fluorinated heteroaromatics in moderate to excellent yields. This one‐pot procedure features a triple‐relay transformation of rapid dearomatization, fluorination, and rearomatization processes, which represents a conceptually novel strategy of combining partial hydrogenation and electrophilic fluorination. |
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| Keywords: | fluorination heterocycles hydrogenation nitro compounds rearomatization |
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