Dual‐Frequency Calcium‐Responsive MRI Agents |
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| Authors: | Dr Pascal Kadjane Prof Dr Carlos Platas‐Iglesias Dr Philipp Boehm‐Sturm Dr Vincent Truffault Dr Gisela E Hagberg Prof Dr Mathias Hoehn Prof Dr Nikos K Logothetis Priv‐Doz Dr Goran Angelovski |
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| Institution: | 1. Department for Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, 72076 Tübingen (Germany);2. Departamento de Química Fundamental, Universidade da Coru?a, 15008 A Coru?a (Spain);3. In‐Vivo‐NMR Laboratory, Max Planck Institute for Neurological Research, 50931 Cologne (Germany);4. Department of Biochemistry, Max Planck Institute for Developmental Biology, 72076 Tübingen (Germany);5. Department of Imaging Science and Biomedical Engineering, University of Manchester, Manchester M13 9PT (UK);6. MR Neuroimaging Agents Group, Max Planck Institute for Biological Cybernetics, 72076 Tübingen (Germany) |
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| Abstract: | Responsive or smart magnetic resonance imaging (MRI) contrast agents are molecular sensors that alter the MRI signal upon changes in a particular parameter in their microenvironment. Consequently, they could be exploited for visualization of various biochemical events that take place at molecular and cellular levels. In this study, a set of dual‐frequency calcium‐responsive MRI agents are reported. These are paramagnetic, fluorine‐containing complexes that produce remarkably high MRI signal changes at the 1H and 19F frequencies at varying Ca2+ concentrations. The nature of the processes triggered by Ca2+ was revealed, allowing a better understanding of these complex systems and their further improvement. The findings indicate that these double‐frequency tracers hold great promise for development of novel functional MRI methods. |
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| Keywords: | calcium fluorine imaging agents magnetic resonance imaging |
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