Magnesium Complexes as Highly Effective Catalysts for Conjugate Cyanation of α,β‐Unsaturated Amides and Ketones |
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| Authors: | Jinlong Zhang Xihong Liu Prof Rui Wang |
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| Institution: | Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Science and Institute of Biochemistry and Molecular Biology School of Life Science, Lanzhou University, Lanzhou, 730000 (P. R. China) |
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| Abstract: | Asymmetric cyanation of trimethylsilyl cyanide (TMSCN) with α,β‐unsaturated amides and ketones, respectively, catalyzed by bifunctional mononuclear 1,1′‐bi‐2‐naphthol (BINOL)–Mg and binuclear bis(prophenol)–Mg catalysts was realized. A series of synthetically important 1,4‐cyano products were obtained with good to high enantioselectivities (up to 97 % ee). |
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| Keywords: | asymmetric catalysis cyanation magnesium synthetic methods unsaturated ketones |
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