Copper‐Mediated ortho‐Nitration of (Hetero)Arenecarboxylates |
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| Authors: | Dr. Dmitry Katayev Kai F. Pfister Timo Wendling Prof. Dr. Lukas J. Gooßen |
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| Affiliation: | FB Chemie‐Organische Chemie, Technische Universit?t Kaiserslautern, Erwin‐Schr?dinger‐Str. Geb. 54, 67663 Kaiserslautern (Germany), Fax: (+49)?631‐205‐3921 |
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| Abstract: | Various (hetero)arenecarboxylic acids were converted to the corresponding Daugulis amides and nitrated selectively in the ortho‐position in the presence of [CuNO3(PPh3)2] and AgNO2 at 50 °C. A microwave‐assisted saponification allows regenerating the carboxylate group within minutes, which may then be removed tracelessly by protodecarboxylation, or substituted by aryl‐ or alkoxy‐groups via decarboxylative cross‐coupling. |
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| Keywords: | carboxylic acids C H activation copper homogeneous catalysis nitration |
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